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84. Late-Stage Diversification of Peptides via Pd-Catalyzed SiteSelective δ‑C(sp2)‑H Fluorination and Amination
84. Late-Stage Diversification of Peptides via Pd-Catalyzed SiteSelective δ‑C(sp2)‑H Fluorination and Amination
Site-selective C−H fluorination is an attractive strategy for directly transforming inert C−H bonds into C−F bonds, yet it remains a significant challenge. Herein, we have developed an efficient and versatile strategy for site-selective fluorination and amination of phenylalanine-containing peptides via late-stage Pd-catalyzed δ-C(sp2)-H activation, providing a valuable tool for the in situ synthesis of fluorinated indoline scaffolds within peptides.
2024-04-22
83. Recent Advances in Computational Study on Cu-Catalyzed Aerobic Reactions: Cooperation of Copper Catalysts  and Dioxygen
83. Recent Advances in Computational Study on Cu-Catalyzed Aerobic Reactions: Cooperation of Copper Catalysts and Dioxygen
O2, one of the ideal oxidants, suffers from low solubility, low oxidizability, low selectivity and a triplet ground state when applied in organic synthesis. Biomimetic copper catalysis has been demonstrated to be a powerful method for activating and transforming O2 to conduct aerobic reactions for a long time. On the other hand, the structures of Cu–O2 complexes are complex with diverse downstream reactions, whereas active copper intermediates were rarely identified by experimental methods, making the mechanisms of many Cu-catalyzed aerobic reactions far from clear. In this context, computational studies emerged as an effective alternative to mechanistic studies on Cu-catalyzed aerobic reactions. This review introduces the relevant computational studies since 2012, focusing on showing the cooperation of copper catalysts and O2 in dehydrogenation, oxygenation and coupling reactions.
2024-04-23
82. Theoretical study on Pd(0)-catalyzed remote C(sp3)-H functionalization via 1,5-Pd migration
82. Theoretical study on Pd(0)-catalyzed remote C(sp3)-H functionalization via 1,5-Pd migration
The remote C(sp3)-H activation/functionalization via 1,5-Pd migration involved in the Pd(0)-catalyzed reaction of (8-bromonaphthalen-1-yl)trimethylsilane (S1) and N-tosylhydrazone (S2) was theoretically investigated with the aid of the density functional theory calculations. The role of the Lewis base LiOtBu was revealed by forming a Pd-O bond to participate in the reaction. The remote C(sp3)-H activation was found to be accomplished by concerted Pd-C(sp2)/C(sp3)-H σ-bond metathesis rather than by stepwise C(sp3)-H oxidative addition/C(sp2)-H reductive elimination. Additionally, the mechanism of generating 2-diazopropane from N-tosylhydrazone (S2) was investigated. This study would be informative and benefit to designing novel relevant transition-metalcatalyzed remote C-H activation/functionalization reactions.
2024-04-23
81. Mechanistic Insights Into the Rhodium-Catalyzed C−H Alkenylation/ Directing Group Migration and [3+2] Annulation: A DFT Study
81. Mechanistic Insights Into the Rhodium-Catalyzed C−H Alkenylation/ Directing Group Migration and [3+2] Annulation: A DFT Study
The mechanism of the rhodium-catalyzed C−H alkenylation/directing group migration and [3+2] annulation of Naminocarbonylindoles with 1,3-diynes has been investigated with DFT calculations. On the basis of mechanistic studies, we mainly focus on the regioselectivity of 1,3-diyne inserting into the Rh−C bond and the N-aminocarbonyl directing group migration involved in the reactions. Our theoretical study uncovers that the directing group migration undergoes a stepwise β-N elimination and isocyanate reinsertion process. As studied in this work, this finding is also applicable to other relevant reactions. Additionally, the role of Na+ versus Cs+ involved in the [3+2] cyclization reaction is also probed.
2024-04-23

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96. Non-C1 Synthon Role of CO2: Promoting Divergent Electrochemical Defluorination
96. Non-C1 Synthon Role of CO2: Promoting Divergent Electrochemical Defluorination
Here, an unpresented non-C1 synthon function of CO2 is reported to facilitate electrochemical defluorination. The introduction of CO2 modulates the electron distribution of the radical anion intermediate generated through one-electron reduction, thereby weakening the reduction potential and facilitating reduction and defluorination. CO2 is released subsequently via spontaneous decarboxylation to complete its promotion role. The presented results shed light on a distinctive utilization of CO2, which may stimulate interest in developing non-C1 synthon functions of CO2.
2025-06-13
95. Transition-Metal-Free Mild and Regioselective Alkylation of Quinoline N-Oxides with Benzylboronates
95. Transition-Metal-Free Mild and Regioselective Alkylation of Quinoline N-Oxides with Benzylboronates
A KOtBu-mediated C2-benzylation of quinoline N-oxides with benzylboronates under mild reaction conditions has been developed. The reaction shows broad scope for both of the quinoline N-oxides and benzylboronates, especially, secondary and tertiary benzylboronates are also compatible with this reaction. DFT calculations indicate that the reaction is promoted by the nucleophilic addition of KOtBu to boronate rather than the deprotonation of benzylic C−H bond with KOtBu.
2025-06-13
94. trans-Ge/B 1,1-Hydroboration of Alkynylgermanes with 9‑BBN
94. trans-Ge/B 1,1-Hydroboration of Alkynylgermanes with 9‑BBN
A 1,1-hydroboration of alkynylgermanes with unique transGe/B stereochemistry under transition-metal-free conditions is reported. Mechanistic studies suggest that a pathway involving α boration followed by a stepwise 1,2-Ge/H shift on the intermediate structurally lies between an alkyne−Ge+ π complex and a typical vinyl cation. The resulting Ge/B bimetallic modules, along with a Ge*/Ge/B trimetallic variant, can be conveniently transformed into trisubstituted olefins through iterative divergent cross-coupling. This work demonstrates that incorporating metalloids into classical organic reactions may offer unconventional chemical selectivity and efficient synthetic applications.
2025-05-25
93. Nickel/Photoredox Catalyzed Aryl-Alkyl Cross-Coupling with Alkyl Boronic Esters as Radical Precursors
93. Nickel/Photoredox Catalyzed Aryl-Alkyl Cross-Coupling with Alkyl Boronic Esters as Radical Precursors
Nickel/photoredox dual catalyzed cross-coupling of aryl halides with alkylboron compounds is one of the effective methodologies for the construction of C(sp2) C(sp3) bonds. Although elegant results have been achieved by using alkyl trifluoroborates as alkyl radical precursors, the generation of alkyl radicals from readily available alkyl boronic esters is still limited due to their high oxidation potential. We disclosed here that activation of alkyl boronic esters by MeOLi is highly efficient for the generation of alkyl radicals under photocatalysis conditions. The reaction featured with a wide substrate scope, high functional group tolerance, and late-stage modification of bioactive substances. In addition, the method was also successfully extended to alkyl boronic acids. Experimental and computational mechanistic studies indicated that the crosscoupling likely proceeds via a Ni(I)-catalyzed pathway.
2024-12-23

最新资讯

96. Non-C1 Synthon Role of CO2: Promoting Divergent Electrochemical Defluorination
96. Non-C1 Synthon Role of CO2: Promoting Divergent Electrochemical Defluorination
Here, an unpresented non-C1 synthon function of CO2 is reported to facilitate electrochemical defluorination. The introduction of CO2 modulates the electron distribution of the radical anion intermediate generated through one-electron reduction, thereby weakening the reduction potential and facilitating reduction and defluorination. CO2 is released subsequently via spontaneous decarboxylation to complete its promotion role. The presented results shed light on a distinctive utilization of CO2, which may stimulate interest in developing non-C1 synthon functions of CO2.
2025-06-13
95. Transition-Metal-Free Mild and Regioselective Alkylation of Quinoline N-Oxides with Benzylboronates
95. Transition-Metal-Free Mild and Regioselective Alkylation of Quinoline N-Oxides with Benzylboronates
A KOtBu-mediated C2-benzylation of quinoline N-oxides with benzylboronates under mild reaction conditions has been developed. The reaction shows broad scope for both of the quinoline N-oxides and benzylboronates, especially, secondary and tertiary benzylboronates are also compatible with this reaction. DFT calculations indicate that the reaction is promoted by the nucleophilic addition of KOtBu to boronate rather than the deprotonation of benzylic C−H bond with KOtBu.
2025-06-13
94. trans-Ge/B 1,1-Hydroboration of Alkynylgermanes with 9‑BBN
94. trans-Ge/B 1,1-Hydroboration of Alkynylgermanes with 9‑BBN
A 1,1-hydroboration of alkynylgermanes with unique transGe/B stereochemistry under transition-metal-free conditions is reported. Mechanistic studies suggest that a pathway involving α boration followed by a stepwise 1,2-Ge/H shift on the intermediate structurally lies between an alkyne−Ge+ π complex and a typical vinyl cation. The resulting Ge/B bimetallic modules, along with a Ge*/Ge/B trimetallic variant, can be conveniently transformed into trisubstituted olefins through iterative divergent cross-coupling. This work demonstrates that incorporating metalloids into classical organic reactions may offer unconventional chemical selectivity and efficient synthetic applications.
2025-05-25
93. Nickel/Photoredox Catalyzed Aryl-Alkyl Cross-Coupling with Alkyl Boronic Esters as Radical Precursors
93. Nickel/Photoredox Catalyzed Aryl-Alkyl Cross-Coupling with Alkyl Boronic Esters as Radical Precursors
Nickel/photoredox dual catalyzed cross-coupling of aryl halides with alkylboron compounds is one of the effective methodologies for the construction of C(sp2) C(sp3) bonds. Although elegant results have been achieved by using alkyl trifluoroborates as alkyl radical precursors, the generation of alkyl radicals from readily available alkyl boronic esters is still limited due to their high oxidation potential. We disclosed here that activation of alkyl boronic esters by MeOLi is highly efficient for the generation of alkyl radicals under photocatalysis conditions. The reaction featured with a wide substrate scope, high functional group tolerance, and late-stage modification of bioactive substances. In addition, the method was also successfully extended to alkyl boronic acids. Experimental and computational mechanistic studies indicated that the crosscoupling likely proceeds via a Ni(I)-catalyzed pathway.
2024-12-23
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