96. Non-C1 Synthon Role of CO2: Promoting Divergent Electrochemical Defluorination

Zhang, Z.;+ Liu, J.;+ Zhang, Z.;  Liu, G.; Jiang, Y.-Y.;* Zhao, Y.* Org. Lett. 2025, ASAP. Download Link

Here, an unpresented non-C1 synthon function of CO2 is reported to facilitate electrochemical defluorination. The introduction of CO2 modulates the electron distribution of the radical anion intermediate generated through one-electron reduction, thereby weakening the reduction potential and facilitating reduction and defluorination. CO2 is released subsequently via spontaneous decarboxylation to complete its promotion role. The presented results shed light on a distinctive utilization of CO2, which may stimulate interest in developing non-C1 synthon functions of CO2.