64. Cascade C-N Bond Cleavage of Amides/Intramolecular Amination Reactions: An Atom Economical Way to α-Cabolin-4-ones

Wang, Y.; Zheng, Z.; Yuan, Y.; Wang, M.; Guo, Z.; Jiang, Y.-Y.;* Bai, L.-P.;* Li, Y.* Org. Chem. Front. 2021, 8, 579-583. Download Link

Abstract: An atom economical approach for the synthesis of α-carbolin-4-ones has been developed. This process was realized via a C–N bond cleavage/intramolecular amination cascade. During this process, one C–N and one C–C bond are cleaved and two C–N and two C–C bonds are formed. Mechanistic studies suggested a migrative N-cyclization process involving a carbene intermediate.